Hurricane Isaias is expected to make landfall within 40 miles east or west of Pensacola, Florida, with the most destructive conditions expected near the storm's center, meaning the area from Pensacola to Panama City could bear the brunt of the hurricane. ▻ ↧ Hurricane Isaias updates: Life-threatening storm surge, devastating... Hurricane Isaias is in the Gulf as it heads toward the Florida Panhandle, where several counties have evacuation orders.